Effective Production of Aromatic Polyketides in Streptomyces using a Combined-Culture Method-Reference-Cited by-同舟云学术

Effective Production of Aromatic Polyketides in Streptomyces using a Combined-Culture Method

Published:2016-07 Issue:7 Volume:11 Page:1934578X1601100
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Hoshino Shotaro¹,Okada Masahiro¹,Onaka Hiroyasu²,Abe Ikuro¹

Affiliation:

1. Department of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan

2. Department of Biotechnology, Graduate School of Agricultural and Life sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan

Abstract

Combined-culture is a fermentation method which efficiently induces secondary metabolite production in Streptomyces by co-culturing them with mycolic acid-containing bacteria. As a result of combined-culture screening of our terrestrial Streptomyces collection using UV-HPLC, one of the tested strains, Streptomyces sp. TAKO-2, produced two known aromatic polyketides, julichrome Q6 (1) and julichrome Q8·8 (2), when co-cultured with the mycolic acid-containing bacterium Tsukamurella pulmonis TP-B0596. The structures of 1 and 2 were confirmed by spectroscopic analysis and literature data.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1601100727

Reference19 articles.

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2. Elucidation of the Tailoring Steps in Julichrome Biosynthesis by Marine Gastropod Mollusk-Associated Streptomyces sampsonii SCSIO 054;Organic Letters;2020-08-21