Oleanane-type Triterpenes with Highly-Substituted Oxygen Functional Groups from the Flower Buds of Camellia sinensis and Their Inhibitory Effects against NO Production and HSV-1-Reference-Cited by-同舟云学术

Oleanane-type Triterpenes with Highly-Substituted Oxygen Functional Groups from the Flower Buds of Camellia sinensis and Their Inhibitory Effects against NO Production and HSV-1

Published:2018-02 Issue:2 Volume:13 Page:1934578X1801300
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Yoneda Taichi¹,Nakamura Seikou¹,Ogawa Keiko¹,Matsumoto Tomoko¹,Nakashima Souichi¹,Matsumura Kiriko¹,Tanaka Aoi¹,Ryu Kaori¹,Fukaya Masashi¹,Fujimuro Masahiro¹,Yoshikawa Masayuki¹,Matsuda Hisashi¹

Affiliation:

1. Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan

Abstract

Acylated oleanane-type triterpenes named chakasapogenins I (1), II (2), and III (3) were isolated from the hydrolysis product of the extract obtained from the flower buds of Camellia sinensis. The chemical structures of new triterpenes were elucidated on the basis of chemical and physicochemical evidence. chakasapogenin III (3) inhibited nitric oxide (NO) production in lipopolysaccharide- (LPS) activated RAW264.7 macrophages. In addition, R1-barrigenol (7) showed antiviral effect at 10μM against herpes simplex virus type-1 (HSV-1).

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1801300206

Reference16 articles.

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5. Oleanolic, Ursolic, and Betulinic Acids as Food Supplements or Pharmaceutical Agents for Type 2 Diabetes: Promise or Illusion?

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