Synthesis and Antimicrobial Characterization of Luotonin Derivatives-Reference-Cited by-同舟云学术

Synthesis and Antimicrobial Characterization of Luotonin Derivatives

Published:2020-12 Issue:12 Volume:15 Page:1934578X2095275
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Zhu Rui¹,Guo Rui²,Han Ke¹,Xi Wenying¹,Zheng Shaojun¹²^ORCID,Zhang Jiwen²

Affiliation:

1. School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang, Jiangsu, P. R. China

2. Key Laboratory of Botanical Pesticide R & D in Shaanxi Province, Northwest A&F University, Yangling, Shaanxi Province, P. R. China

Abstract

Twenty-one novel luotonin derivatives were synthesized from 2-aminobenzamide in excellent yields. The prepared compounds, when tested against 8 strains of bacteria and many plant pathogen fungi showed diverse and promising antimicrobial activities. Notably, compounds a5, a9, b4, and b5 demonstrated good activities and might be potential lead compounds for further development as antifungal agents. The relationship between structure and biological activity is also discussed.

Funder

the Natural Science Foundation of Jiangsu Province

Zhoushan public welfare science and technology project

the National Natural Science Foundation of China

the Key Research and Development Program (Modern Agriculture) of Zhenjiang City

the National Key Research and Development Program of China

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X20952750