Three New 18-Oxygenated ent-Kaurane Diterpenoids from Isodon leucophyllus-Reference-Cited by-同舟云学术

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Three New 18-Oxygenated ent-Kaurane Diterpenoids from Isodon leucophyllus

Published:2010-12 Issue:12 Volume:5 Page:1934578X1000501
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Zhang Hai Bo¹²,Pu Jian Xin¹,Zhao Yong¹,He Fei¹,Zhao Wei¹,Lou Li Guang³,Xiao Wei Lie¹,Sun Han Dong¹

Affiliation:

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China

2. Graduate University of Chinese Academy of Sciences, Beijing 100039, China

3. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

Abstract

Three new 18-oxygenated ent-kaurane diterpenoids, isoleuconins A-C (1–3) and ten known diterpenoids were isolated from the aerial parts of Isodon leucophyllus. The structures were elucidated by 1D and 2D NMR spectroscopic analysis. All of the compounds were evaluated for their cytotoxicity. Rabdokunmin A (13) showed significant cytotoxicity against HT-29 cells, with an IC50 value of 6.2 μM.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1000501206

Reference14 articles.

1. LiaoX, DingLS, PengSL. (1998) ent-Kaurane diterpenoids from Rabdosia leucophylla. Phytochemistry, 47 247-250;

2. Diterpenoids fromIsodon leucophyllus1

3. Cytotoxicent-kauranoids fromIsodon leucophyllus

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