A New C23 Steroid from the Venom of Bufo Bufo Gargarizans-Reference-Cited by-同舟云学术

A New C23 Steroid from the Venom of Bufo Bufo Gargarizans

Published:2015-08 Issue:8 Volume:10 Page:1934578X1501000
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Luo Shi-Lin¹²,Tian Hai-Yan¹,Liu Jun-Shan¹³,Wang Ying¹,Ye Wen-Cai¹

Affiliation:

1. Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China

2. Institute of Clinical Pharmacy, the Second Xiangya Hospital, Central South University, Changsha 410011, PR China

3. School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, PR China

Abstract

A new C23 steroid, (3β,5β,14β)-methyl (3-hydroxy-14,15-epoxy-20-oxo-21-norcholan-24-oate) (1), together with four known ones (2–5), were isolated from the venom of Bufo bufo gargarizans. Their structures were elucidated on the basis of extensive spectroscopic analysis. The cytotoxicity of these compounds was also evaluated against human hepatocarcinoma HepG2 cells. Compound 3 showed significant cytotoxicity with an IC50 value of 16.8±0.7 μM.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1501000809

Reference13 articles.

1. Editorial Committee of the Administration Bureau of Traditional Chinese Medicine. (1999) Chinese Materia Medica (ZhonghuaBencao), Shanghai Science and Technology Press, Shanghai, 362–367;

2. Effects of Chan Su, a traditional Chinese medicine, on the calcium transients of isolated cardiomyocytes: Cardiotoxicity due to more than Na, K-ATPase blocking

3. Preparative Separation of Four Major Bufadienolides from the Chinese Traditional Medicine, Chansu, Using High-Speed Counter-Current Chromatography

4. Analysis of bufadienolides in the Chinese drug ChanSu by high-performance liquid chromatography with atmospheric pressure chemical ionization tandem mass spectrometry

5. Simultaneous Quantification of Seven Major Bufadienolides in Three Traditional Chinese Medicinal Preparations of ChanSu by HPLC-DAD

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Bufadienolides from the Venom of Bufo Bufo gargarizans and Their Enzyme Inhibition Activities and Brine Shrimp Lethality;Natural Product Communications;2018-07

2. Cinobufacini from the Skin of Bufo bufo gargarizans Induces Apoptosis, Possibly via Activation of the Wnt/β-Catenin Pathway, in Human Osteosarcoma Cells;Natural Product Communications;2018-02