Isolation of Monovalerianester A, an Inhibitor of Fat Accumulation, from Valeriana Fauriei-Reference-Cited by-同舟云学术

Isolation of Monovalerianester A, an Inhibitor of Fat Accumulation, from Valeriana Fauriei

Published:2015-08 Issue:8 Volume:10 Page:1934578X1501000
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Yuki Keiji¹,Ikeda Mariko¹,Yoshida Shosuke¹,Ohno Osamu²,Suenaga Kiyotake²,Yamada Kaoru³,Uemura Daisuke³,Miyamoto Kenji¹

Affiliation:

1. Department of Biosciences and Informatics, Keio University, 3–14–1 Hiyoshi, Yokohama, 223–8522, Japan

2. Department of Chemistry, Keio University, 3–14–1 Hiyoshi, Yokohama, 223–8522, Japan

3. Department of Chemistry, Kanagawa University, 2946 Tsuchiya, Hiratsuka, 256–1293, Japan

Abstract

The rhizomes and roots of Valeriana fauriei were extracted with 80% aqueous ethanol. This extract was found to exhibit potent inhibitory effects on fat accumulation in 3T3-L1 murine adipocytes. After several steps of chromatographic purification, we succeeded in identifying monovalerianester A as an inhibitor of fat accumulation. Thus, monovalerianester A and the crude extract of the rhizomes and roots of V. fauriei may have therapeutic potential for the treatment of obesity.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1501000801

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