Clocks, Viruses, and Immunity: Lessons for the COVID-19 Pandemic-Reference-Cited by-同舟云学术

Clocks, Viruses, and Immunity: Lessons for the COVID-19 Pandemic

Published:2021-01-22 Issue:1 Volume:36 Page:23-34
ISSN:0748-7304
Container-title:Journal of Biological Rhythms
language:en
Short-container-title:J Biol Rhythms

Author:

Sengupta Shaon¹²³⁴^ORCID,Ince Louise⁵,Sartor Francesca⁶,Borrmann Helene⁷^ORCID,Zhuang Xiaodong⁷^ORCID,Naik Amruta²,Curtis Annie⁸,McKeating Jane A.⁷⁹^ORCID

Affiliation:

1. Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

2. Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

3. Institute of Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, USA

4. Chronobiology and Sleep Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA

5. Departement de Pathologie et Immunologie, Geneva, Switzerland

6. Institute of Medical Psychology, Medical Faculty, Ludwig Maximilian University of Munich, Munich, Germany

7. Nuffield Department of Medicine, University of Oxford, Oxford, UK

8. School of Pharmacy and Biomolecular Sciences, Tissue Engineering Research Group, Royal College of Surgeons in Ireland, Dublin, Ireland

9. Chinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, UK

Abstract

Circadian rhythms are evolutionarily conserved anticipatory systems that allow the host to prepare and respond to threats in its environment. This article summarizes a European Biological Rhythms Society (EBRS) workshop held in July 2020 to review current knowledge of the interplay between the circadian clock and viral infections to inform therapeutic strategies against SARS-CoV-2 and COVID-19. A large body of work supports the role of the circadian clock in regulating various aspects of viral replication, host responses, and associated pathogenesis. We review the evidence describing the multifaceted role of the circadian clock, spanning host susceptibility, antiviral mechanisms, and host resilience. Finally, we define the most pressing research questions and how our knowledge of chronobiology can inform key translational research priorities.

Funder

National Heart, Lung, and Blood Institute

MRC

Science Foundation Ireland

Volkswagen Foundation

Irish Research Council

Wellcome Trust

chinese academy of medical sciences

Publisher

SAGE Publications

Subject

Physiology (medical),Physiology