Light Treatment for Sleep Disorders: Consensus Report

Author:

Terman Michael1,Lewy Alfred J.2,Dijk Derk-Jan3,Boulos Ziad4,Eastman Charmane I.5,Campbell Scott S.6

Affiliation:

1. Department of Psychiatry, Columbia University and New York State Psychiatric Institute, 722 West 168th Street, New York, NY 10032

2. Department of Psychiatry, Oregon Health Sciences University, 3181 S.W. Sam Jackson Park Road, Portland, OR 97201

3. Institute of Pharmacology, University of Zürich, Winterthurerstrasse 190, CH-8057, Zürich, Switzerland

4. Institute for Circadian Physiology, 1 Alewife Center, Cambridge, MA 02140

5. Biological Rhythms Research Laboratory, Rush-Presbyterian-St. Luke's Medical Center, 1653 West Congress Parkway, Chicago, IL 60612

6. Laboratory of Human Chronobiology, New York Hospital, Cornell University Medical College, 21 Bloomingdale Road, White Plains, NY 10605

Abstract

Advanced and delayed sleep phase disorders, and the hypersomnia that can accompany winter depression, have been treated successfully by appropriately timed artificial bright light exposure. Under entrainment to the 24-h day-night cycle, the sleep-wake pattern may assume various phase relationships to the circadian pacemaker, as indexed, for example, by abnormally long or short intervals between the onset of melatonin production or the core body temperature minimum and wake-up time. Advanced and delayed sleep phase syndromes and non-24-h sleep-wake syndrome have been variously ascribed to abnormal intrinsic circadian periodicity, deficiency of the entrainment mechanism, or—most simply—patterns of daily light exposure insufficient for adequate phase resetting. The timing of sleep is influenced by underlying circadian phase, but psychosocial constraints also play a major role. Exposure to light early or late in the subjective night has been used therapeutically to produce corrective phase delays or advances, respectively, in both the sleep pattern and circadian rhythms. Supplemental light exposure in fall and winter can reduce the hypersomnia of winter depression, although the therapeutic effect may be less dependent on timing.

Publisher

SAGE Publications

Subject

Physiology (medical),Physiology

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