The Voices of Stakeholders Involved in Precision Medicine: The Co-Design and Evaluation of Qualitative Indicators of Intervention Acceptability, Fidelity and Context in PRecISion Medicine for Children With Cancer in Australia-Reference-Cited by-同舟云学术

The Voices of Stakeholders Involved in Precision Medicine: The Co-Design and Evaluation of Qualitative Indicators of Intervention Acceptability, Fidelity and Context in PRecISion Medicine for Children With Cancer in Australia

Published:2022-09-06 Issue:12 Volume:32 Page:1865-1880
ISSN:1049-7323
Container-title:Qualitative Health Research
language:en
Short-container-title:Qual Health Res

Author:

Smith James¹^ORCID,Braithwaite Jeffrey¹^ORCID,O’Brien Tracey A.²³,Smith Stephanie⁴⁵⁶,Tyrrell Vanessa J.⁷,Mould Emily V. A.⁷,Long Janet C.¹,Rapport Frances¹^ORCID

Affiliation:

1. Centre for Healthcare Resilience and Implementation Science, Australian Institute of Health Innovation, Macquarie University, Sydney, NSW, Australia

2. Faculty of Medicine, School of Women’s and Children’s Health, University of New South Wales, Sydney, NSW, Australia

3. Kids Cancer Centre, Sydney Children’s Hospital, Randwick, NSW, Australia

4. School of Population Health, Curtin University, Perth, WA, Australia

5. School of Nursing and Midwifery, Edith Cowan University, Perth, WA, Australia

6. Perth Children’s Hospital, Nedlands, WA, Australia

7. Children’s Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Randwick, NSW, Australia

Abstract

We report a novel approach of amalgamating implementation outcomes of acceptability and fidelity alongside context as a new way of qualitatively evaluating implementation outcomes and context of a precision medicine intervention. A rapid qualitative online proforma was co-designed with stakeholders and sent to a purposive sample of healthcare professionals involved in an early-phase clinical trial intervention. Data were analysed using Framework Analysis. A total of 24 out of 68 proformas were returned. Although some participants raised concerns about drug medication access issues, the main intervention was well accepted and understood across professional groups. Comprehension was enhanced through exposure to specialist multidisciplinary meeting arrangements. In conclusion, a rapid data collection tool and framework are now available to assess readily measurable, qualitative indicators of acceptability, fidelity of receipt and contextual fit within the dynamic precision medicine context.

Funder

NSW Health

Publisher

SAGE Publications

Subject

Public Health, Environmental and Occupational Health

Link

http://journals.sagepub.com/doi/pdf/10.1177/10497323221120501

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