Clostridial Hepatic Gas Gangrene with Massive Intravascular Haemolysis and Acute Renal Failure: A Case Report and Literature Review

Abstract

Clostridial hepatic gas gangrene is a rare but highly fatal disease. We report a complicated case of clostridial hepatic gas gangrene, presented with short history of fever, followed by severe back pain and systemic hypertension. Urgent contrast computed tomogram (CT) thorax and abdomen was performed to rule out aortic dissection. Instead, a gas-forming lesion was found in the liver, with multiple areas of hepatic venous gas. Also, CT showed poor renal contrast excretion, indicating acute renal failure. Unexpectedly, the patient developed cardiac arrest shortly after imaging and succumbed despite active resuscitation. Repeated biochemical tests showed gross hemolysis. Autopsy revealed generalised autolytic changes in internal organs with abundance of Gram positive bacilli. The overall picture was compatible with clostridial hepatic gas gangrene, with massive intravascular haemolysis and acute renal failure. Upon literature review, the importance of early diagnosis and aggressive management is highlighted.