Interleukin-6 in Surgery, Trauma, and Critical Care Part II: Clinical Implications-Reference-Cited by-同舟云学术

Interleukin-6 in Surgery, Trauma, and Critical Care Part II: Clinical Implications

Published:2010-11-30 Issue:2 Volume:26 Page:73-87
ISSN:0885-0666
Container-title:Journal of Intensive Care Medicine
language:en
Short-container-title:J Intensive Care Med

Author:

Jawa Randeep S.¹,Anillo Sergio²,Huntoon Kristin³,Baumann Heinz³,Kulaylat Mahmoud²

Affiliation:

1. Department of Surgery, University of Nebraska Medical Center, Omaha, NE, USA,

2. Department of Surgery, SUNY Buffalo, Buffalo, NY, USA

3. Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY, USA

Abstract

A variety of cytokines play a role in the inflammatory response. Interleukin-6 (IL-6)-type cytokines are released in response to tissue injury or an inflammatory stimulus, and act locally and systemically to generate a variety of physiologic responses. Interleukin-6 concentrations are elevated after surgery, trauma, and critical illness. The magnitude of IL-6 elevation correlates with the extent of tissue trauma/injury severity. Furthermore, there is an association between IL-6 elevation and adverse outcome. Interleukin-6 levels can also be used to stratify patients for therapeutic intervention.

Publisher

SAGE Publications

Subject

Critical Care and Intensive Care Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/0885066610384188

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