Pharmacologic Management of Delirium in the ICU: A Review of the Literature

Author:

Korenoski Amanda1,Li Angela2,Kane-Gill Sandra L.3,Seybert Amy L.3,Smithburger Pamela L.3ORCID

Affiliation:

1. Department of Pharmacy, Pharmacy and Therapeutics, Pittsburgh Poison Center of UPMC, UPMC Presbyterian Hospital, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, USA

2. University of Pittsburgh School of Pharmacy, Pittsburgh, PA, USA

3. Department of Pharmacy, Pharmacy and Therapeutics, UPMC Presbyterian Hospital, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, USA

Abstract

Purpose: Conflicting data exists on the pharmacologic management of intensive care unit (ICU) delirium. This review appraises the current evidence of pharmacologic management of ICU delirium. Materials and Methods: A systematic literature search of MEDLINE and Embase was conducted to answer the population, intervention, comparison, and outcome (PICO) question of: “Does the use of a pharmacologic agent compared to standard of care or placebo improve ICU delirium in a critically ill patient population?” Results: After application of the PICO question and the inclusion and exclusion criteria, 13 articles were included. Of these articles, 7 were prospective randomized controlled trials, 1 was a prospective nonrandomized controlled trial, and 5 were retrospective investigations. The included articles differed in the agents evaluated, primary outcome, and method of identifying delirium. Conclusion: The variability of outcomes illustrates the need for a large-scale investigation to further evaluate the role of pharmacologic management of ICU delirium.

Publisher

SAGE Publications

Subject

Critical Care and Intensive Care Medicine

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