Affiliation:
1. Department of Surgery, National Defense Medical College Research Institute, Saitama, Japan,
2. Department of Surgery, National Defense Medical College Research Institute, Saitama, Japan
Abstract
To disclose the participation of neutrophils in septic acute respiratory distress syndrome (ARDS), characteristics of various inflammatory mediators were examined in septic patients. Forty-seven gram-negative septic patients were divided into ARDS (n = 23) and non-ARDS (n = 24) groups at the transferred point to the intensive care unit. The mediators were measured simultaneously at the transferred point, and then subsequently on days 1, 3, and 5. At the transferred point, the ARDS group showed significantly higher levels of interleukin-8 (IL-8), macrophage inflammatory peptide-1-alpha (MIP-1-α), soluble intercellular adhesion molecule-1 (sICAM-1), and neutrophil elas-tase despite lower neutrophil counts compared to the non-ARDS group. The ARDS group sustained significantly higher levels of sICAM-1 until day 5 and neutrophil elas-tase until day 1 compare to the non-ARDS group. Furthermore, nonsurviving ARDS patients (n = 8) showed significantly higher levels of tumor necrosis factor-alpha, IL-6, IL-8, and IL-10 compared to surviving ARDS patients (n = 15) at the transferred point. In conclusion, neutrophil-related inflammatory mediators, IL-8, MIP-1-α, sICAM-1, and neutrophil elastase, appear to possibly participate in septic ARDS. Cytokines might also play an important role in the mortality of such cases.
Subject
Critical Care and Intensive Care Medicine
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献