Sedation in Neonatal and Pediatric Intensive Care

Abstract

Despite the widespread use of potent sedative and analgesic agents in adult patients, it is remarkable that systemic analgesia and sedation have not been administered routinely to neonates and children until very recently. Adequate sedation and analgesia have historically been withheld from these patients because of the mistaken beliefs that pain perception was not fully developed and that these patients were much more prone to adverse effects of the most commonly used agents. There is now overwhelming evidence that pain perception and physiologic responses to stress are present in neonates of all gestational ages and a variety of effective sedative/analgesic agents have recently been added to the therapeutic armamentarium. We will outline the classes of agents currently available, briefly describe mechanisms of action and the relevant pharmacokinetic—pharmacodynamic parameters, summarize the short-term and long-term side effects following prolonged administration of these agents, and highlight practical considerations for the most commonly used sedative-analgesic medications.