Fatal Rapidly Progressive Interstitial Pneumonitis Associated With Amyopathic Dermatomyositis and CD8 T Lymphocytes

Author:

Yokoyama Toshinobu1,Sakamoto Teruo2,Shida Norihiko2,Kinoshita Masaharu3,Kunou Yoshifumi2,Karukaya Ritsuko2,Takamatsu Manabu2,Aizawa Hisamichi3

Affiliation:

1. First Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan,

2. Emergency and Critical Care Medical Center, Kurume University School of Medicine, Kurume, Japan

3. First Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan

Abstract

A patient with amyopathic dermatomyositis associated with fatal rapidly progressive interstitial pneumonitis resistant to therapy is described. Pathologic examination of a transbronchial lung biopsy specimen showed diffuse alveolar damage and nonspecific interstitial pneumonia-organizing pneumonia-like findings. Bronchoalveolar lavage fluid contained many CD8+ lymphocytes, considered to be cytotoxic T cells. Analysis of bronchoalveolar lavage fluid in this case may provide prognostically and pathogenetically important information.

Publisher

SAGE Publications

Subject

Critical Care and Intensive Care Medicine

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