Clinical significance of serum GPX2 levels in patients with osteoarthritis was suppressed and reduced inflammation of osteoarthritis through STAT3 function

Abstract

The main alterations of osteoarthritis are degenerative lesions of articular cartilage and secondary hyperostosis. Despite the unclear pathogenic mechanism, experimental studies have confirmed that the incidence of osteoarthritis is closely associated with inflammation-related substances. In this study, we explored the significance of serum GPX2 levels in patients with osteoarthritis and the mechanism of GPX2 in the anti-inflammation effects in osteoarthritis. As a result, serum GPX2 level was down-regulated and there was a negative correlation between GPX2 levels and IL-1β levels in patients with osteoarthritis. Over-expression of GPX2 decreased the inflammatory levels and down-regulation of GPX2 increased inflammatory levels in vitro. In contrast, GPX2 combined and regulated STAT3 protein expression. Over-expression of GPX2 promoted ubiquitination-STAT3 protein expression to decrease p-STAT3 protein expression in vitro. The inhibition of STAT3 attenuated the anti-inflammation effects of GPX2 in osteoarthritis. Thus, we proposed that GPX2 was down-regulated in patients with osteoarthritis and GPX2 played vital roles in osteoarthritis for clinical diagnosis or therapy.