Affiliation:
1. Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Zhenjiang, China
2. School of Medicine, Jiangsu University, Zhenjiang, China
Abstract
Pancreatic cancer is one of the most lethal diseases around the world, for hardly detection and poor prognosis. Recent years, functions of the tumor microenvironment and immune cells attract people’s view and there is emerging evidence implicating some immune cells hold the key points in the metabolism, invasion, and metastasis in pancreatic cancer. In this review, we highlight some main immune cells, such as Tumor-associated neutrophils (TANs) and macrophages (TAMs), Pancreatic stellate cells (PSCs), Myeloid-derived suppressor cells (MDSCs), and Regulatory T cells (Tregs). Furthermore, we review current clinical applications and discuss potential values in future.
Funder
National Natural Science Foundation of China
Provincial Natural Science Foundation of Jiangsu, China
Jiangsu Key R & D Program Social Development Project, China
Research Programs of Jiangsu Provincial Commission of Health and Family Planning, China
“Six one Project” Research Projects of High-level Medical Personnel of Jiangsu Province
“Six Talents Peak” High-level Talent Selection and Training Project of Jiangsu Province
Science and Technology Support Program Project of Zhenjiang, China
Subject
Immunology,Immunology and Allergy,General Medicine
Cited by
2 articles.
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