Author:
Duncan John J.,Farr James E.
Abstract
A randomized, double-blind, parallel-group clinical trial compared diclofenac sodium (Voltaren, Ciba-Geigy Summit, NJ) with aspirin for the treatment of acute sprains and/or strains of the knee or ankle. One hundred thirty-nine patients were admitted to the study. Patients received either 150 mg (75 mg twice daily) of diclofenac (N = 69) or 3.6 g (1.2 g three times daily) of aspirin (N = 70) for 3 to 10 days. Forty-seven diclofenac patients and 49 aspirin patients, mean age for both groups 25 years, were evaluated to determine the efficacy of each treatment. Both groups experienced significant (P < 0.001) improvements for all efficacy variables measured. Treating sprains and strains with diclofenac rather than with aspirin allowed an earlier return to activity. Of those patients who achieved play ing fitness, those in the diclofenac group resumed athletic activities in a mean of 4.7 days, compared with a mean of 5.9 days for patients in the aspirin group. Although the overall multivariate F was nonsignificant (P = 0.19), the univariate F for days required to resume playing fitness was significantly (P = 0.025) shorter in the diclofenac group. While the nonsignificant multivar iate result suggests that the significance may be due to chance, it is also possible that there was a trend toward earlier resumption of activities with diclofenac treatment compared to aspirin, but an insufficient sam ple size to demonstrate the trend statistically. Since others have reported such a trend without the greater controls of a multivariate analysis, this area warrants further research.
Subject
Physical Therapy, Sports Therapy and Rehabilitation,Orthopedics and Sports Medicine
Reference4 articles.
1. A Survey of Overuse Running Injuries
2. Ehrlich G. Primary drug therapy Aspirin vs. the nonsteroidal anti-inflammatory drugs Postgrad Med (Special Report): 9-17, 1983
3. Hamstring/Quadriceps Strength Ratios in Collegiate Middle-Distance and Distance Runners
4. Van Heerden JJ Diclofenac sodium, oxyphenbutazone and placebo in sports injuries of the knee. S Afr Med J 52. 396-399, 1977
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