Affiliation:
1. Royal Prince Alfred Hospital, Camperdown, N.S.W.
2. Wollongong Hospital.
Abstract
Serious complications from tricyclic antidepressant (TCA) overdose are uncommon1,2,3. We present a case of massive imipramine overdose complicated by ventricular fibrillation and a prolonged period of cardiovascular collapse. A total of 400 mmol of sodium bicarbonate, 5 mg of adrenaline and 80 mg of sotalol were given during 50 minutes of cardiac arrest. The patient made a full recovery with no apparent neurological sequelae. The highest TCA plasma level we could find in the published literature was 4873 ng/ml4; our patient's peak TCA level was 6000 ng/ml. Tricyclic antidepressant overdose is a common cause of intensive care unit admission. It has a low mortality rate.
Subject
Anesthesiology and Pain Medicine,Critical Care and Intensive Care Medicine
Cited by
27 articles.
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