The Comparative Effects of Propofol versus Thiopentone on Left Ventricular Function during Electroconvulsive Therapy

Abstract

The purpose of this study was to compare the effect of propofol versus thiopentone on haemodynamics during electroconvulsive therapy (ECT), as estimated by echocardiography. Twenty-eight ASA 1 or 2 patients scheduled for ECT were randomly divided into two groups, to receive propofol 1 mg/kg (propofol group, n=14) or thiopentone 2 mg/kg (thiopentone group, n=14). Bilateral ECT was performed after the administration of propofol or thiopentone, succinylcholine and following assisted mask ventilation with 100% oxygen. Cardiac function was examined by transthoracic echocardiography, prior to induction of anaesthesia and throughout ECT until ten minutes after the seizure. In the propofol group, increased end-systolic area (ESA) and decreased fractional area change (FAC) were observed at one minute after the electrical shock compared with the awake condition. In the thiopentone group, increased ESA and decreased FAC were observed from one to three minutes after the electrical shock compared with the awake condition. There was no statistically significant change in after load in the propofol group during the study. In contrast, increased after load was observed from one to three minutes after the electrical shock in the thiopentone group (awake condition, 26±7 mmHg/cm 2 [mean±SD]; one minute after ECT, 42±7*; two minutes after ECT, 44±6*; three minutes after ECT; 40±5*, respectively)(*P<0.05). We concluded that a lesser haemodynamic change occurs after propofol anaesthesia (1 mg/kg) compared with thiopentone anaesthesia (2 mg/kg) during ECT.