Cardiovascular and Subjective Central Nervous System Effects of Long-Acting Local Anaesthetics in Man-Reference-Cited by-同舟云学术

Cardiovascular and Subjective Central Nervous System Effects of Long-Acting Local Anaesthetics in Man

Published:1979-08 Issue:3 Volume:7 Page:215-221
ISSN:0310-057X
Container-title:Anaesthesia and Intensive Care
language:en
Short-container-title:Anaesth Intensive Care

Author:

Mather Laurence E.¹²,Tucker Geoffrey T.¹³,Murphy T. M.¹⁴,Stanton-Hicks M. d'A.¹⁵,Bonica J. J.¹⁴

Affiliation:

1. University of Washington, Seattle

2. Department of Anesthesiology, University of Washington, Department of Anaesthesia and Intensive Care, Flinders Medical Centre, Adelaide.

3. Department of Anesthesiology, University of Washington, Department of Therapeutics, University of Sheffield.

4. Department of Anesthesiology, University of Washington.

5. Department of Anesthesiology, University of Washington, Department of Anesthesia, University of Massachusetts Medical School.

Abstract

Intravenous infusions of etidocaine 50, 75 and 100 mg and bupivacaine 75 mg were carried out over ten minutes in healthy young adult males. Cardiovascular sequelae were generally trivial at all doses. A collection of subjective central nervous system symptoms were described which may be regarded as early warning of impending local anaesthetic toxicity. Plasma concentrations of etidocaine were proportional to dose and ranged from 2 μg/ml to 5 μg/ml at the termination of the infusion. Plasma concentrations of bupivacaine were similar to those from the same dose of etidocaine but declined more slowly on cessation of infusion.

Publisher

SAGE Publications

Subject

Anesthesiology and Pain Medicine,Critical Care and Intensive Care Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/0310057X7900700302

Reference15 articles.

1. Effects of Mepivacaine (Carbocaine®) on Femoral Blood Flow in the Dog

2. Circulatory Effects of Peridural Block

3. Epidural Block for Abdominal Surgery: Aspects of Clinical Pharmacology of Etidocaine

4. Some Nonparametric Statistical Tests for Quick Evaluation of Clinical Data

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