The Introduction of Halothane into Clinical Practice: The Oxford Experience

Author:

O'Brien H. D.1

Affiliation:

1. Formerly Department of Anaesthetics, The Prince of Wales Hospital, Sydney, New South Wales, Australia

Abstract

This paper reviews the clinical situation in anaesthesia before the introduction of halothane into clinical practice in 1956, emphasising the limitations of agents available at the time. The background to the development of halogenated hydrocarbon compounds as anaesthesia agents is presented, including the involvement of Imperial Chemical Industries in England. The Nuffield Department of Anaesthetics was involved in the clinical trials and the designing and execution of these. The results of their work and the problems encountered are presented.

Publisher

SAGE Publications

Subject

Anesthesiology and Pain Medicine,Critical Care and Intensive Care Medicine

Cited by 5 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Pharmacology of Inhaled Anesthetics;Pharmacology and Physiology for Anesthesia;2019

2. An Anesthesiologist’s Perspective on the History of Basic Airway Management;Anesthesiology;2018-02-01

3. Pharmacology of Inhaled Anesthetics;Pharmacology and Physiology for Anesthesia;2013

4. Current World Literature;Current Opinion in Anaesthesiology;2007-06

5. Halothane;Anaesthesia and Intensive Care;2007-04

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