The transient intraluminal filament middle cerebral artery occlusion model as a model of endovascular thrombectomy in stroke-Reference-Cited by-同舟云学术

The transient intraluminal filament middle cerebral artery occlusion model as a model of endovascular thrombectomy in stroke

Published:2015-10-02 Issue:2 Volume:36 Page:363-369
ISSN:0271-678X
Container-title:Journal of Cerebral Blood Flow & Metabolism
language:en
Short-container-title:J Cereb Blood Flow Metab

Author:

Sutherland Brad A¹,Neuhaus Ain A¹,Couch Yvonne¹,Balami Joyce S²³,DeLuca Gabriele C⁴,Hadley Gina¹,Harris Scarlett L¹,Grey Adam N¹,Buchan Alastair M¹

Affiliation:

1. Acute Stroke Programme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK

2. Centre for Evidence Based Medicine, University of Oxford, Oxford, UK

3. Norfolk and Norwich University Teaching Hospital NHS Trust, Norwich, UK

4. Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK

Abstract

The clinical relevance of the transient intraluminal filament model of middle cerebral artery occlusion (tMCAO) has been questioned due to distinct cerebral blood flow profiles upon reperfusion between tMCAO (abrupt reperfusion) and alteplase treatment (gradual reperfusion), resulting in differing pathophysiologies. Positive results from recent endovascular thrombectomy trials, where the occluding clot is mechanically removed, could revolutionize stroke treatment. The rapid cerebral blood flow restoration in both tMCAO and endovascular thrombectomy provides clinical relevance for this pre-clinical model. Any future clinical trials of neuroprotective agents as adjuncts to endovascular thrombectomy should consider tMCAO as the model of choice to determine pre-clinical efficacy.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine,Clinical Neurology,Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1177/0271678X15606722

Reference37 articles.

1. Tissue Plasminogen Activator for Acute Ischemic Stroke

2. Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials

3. PROACT: A Phase II Randomized Trial of Recombinant Pro-Urokinase by Direct Arterial Delivery in Acute Middle Cerebral Artery Stroke

4. The Penumbra System: A Mechanical Device for the Treatment of Acute Stroke due to Thromboembolism

5. Safety and Efficacy of Mechanical Embolectomy in Acute Ischemic Stroke

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