A critical role for the ATP-sensitive potassium channel subunit KIR6.1 in the control of cerebral blood flow

Author:

Hosford Patrick S12,Christie Isabel N23,Niranjan Arun3,Aziz Qadeer1,Anderson Naomi1,Ang Richard2,Lythgoe Mark F3,Wells Jack A3,Tinker Andrew1,Gourine Alexander V2

Affiliation:

1. William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, UK

2. Centre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology & Pharmacology, University College London, London, UK

3. UCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, UK

Abstract

KIR6.1 (KCNJ8) is a subunit of ATP sensitive potassium channel (KATP) that plays an important role in the control of peripheral vascular tone and is highly expressed in brain contractile cells (vascular smooth muscle cells and pericytes). This study determined the effect of global deletion of the KIR6.1 subunit on cerebral blood flow, neurovascular coupling and cerebral oxygenation in mice. In KIR6.1 deficient mice resting cerebral blood flow and brain parenchymal partial pressure of oxygen ( PO2) were found to be markedly lower compared to that in their wildtype littermates. However, cortical blood oxygen level dependent responses triggered by visual stimuli were not affected in conditions of KIR6.1 deficiency. These data suggest that KATP channels containing KIR6.1 subunit are critically important for the maintenance of normal cerebral perfusion and parenchymal PO2 but play no significant role in the mechanisms underlying functional changes in brain blood flow.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine,Neurology (clinical),Neurology

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