Recanalization, reperfusion, and recirculation in stroke

Author:

Zhang John H1ORCID,Obenaus Andre1,Liebeskind David S2,Tang Jiping1,Hartman Richard1,Pearce William J1

Affiliation:

1. Center for Neuroscience Research, Loma Linda University School of Medicine, Loma Linda, CA, USA

2. Neurovascular Imaging Research Core and Department of Neurology, UCLA, CA, USA

Abstract

Recirculation, from arterial inflow routes through venous outflow pathways, was conceptualized in stroke research 50 years ago. As new technologies were developed, blocked arteries could be reopened, capillaries could be reperfused, and the use of recanalization and reperfusion grew to dominate therapeutic strategies. These approaches overwhelmingly focused on restoration of arterial and capillary inflow, but not on veins even though venous disorders may initiate or exacerbate brain injury. In this commentary, we advance the term “recirculation” after “recanalization” and “reperfusion” as a primary concept of stroke pathophysiology that targets the restoration of both the arterial and venous cerebral circulations.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine,Neurology (clinical),Neurology

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