Impaired response of cerebral oxygen metabolism to visual stimulation in Huntington’s disease-Reference-Cited by-同舟云学术

Impaired response of cerebral oxygen metabolism to visual stimulation in Huntington’s disease

Published:2020-08-17 Issue:5 Volume:41 Page:1119-1130
ISSN:0271-678X
Container-title:Journal of Cerebral Blood Flow & Metabolism
language:en
Short-container-title:J Cereb Blood Flow Metab

Author:

Klinkmueller Peter¹²³,Kronenbuerger Martin⁴⁵⁶,Miao Xinyuan²³,Bang Jee⁴⁵,Ultz Kia E⁴,Paez Adrian²³,Zhang Xiaoyu²³,Duan Wenzhen⁵⁷,Margolis Russell L⁵⁸,Zijl Peter CM van²³,Ross Christopher A⁵⁷⁸,Hua Jun²³

Affiliation:

1. Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD, USA

2. F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA

3. Neurosection, Division of MRI Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA

4. Division of Movement Disorders, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA

5. Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA

6. Department of Neurology, University of Greifswald, Greifswald, Germany

7. Departments of Neuroscience and Pharmacology, Johns Hopkins University School of Medicine, Baltimore, MD, USA

8. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA

Abstract

Huntington’s disease (HD) is a neurodegenerative disease caused by a CAG triplet repeat expansion in the Huntingtin gene. Metabolic and microvascular abnormalities in the brain may contribute to early physiological changes that subserve the functional impairments in HD. This study is intended to investigate potential abnormality in dynamic changes in cerebral blood volume (CBV) and cerebral blood flow (CBF), and cerebral metabolic rate of oxygen (CMRO2) in the brain in response to functional stimulation in premanifest and early manifest HD patients. A recently developed 3-D-TRiple-acquisition-after-Inversion-Preparation magnetic resonance imaging (MRI) approach was used to measure dynamic responses in CBV, CBF, and CMRO2 during visual stimulation in one single MRI scan. Experiments were conducted in 23 HD patients and 16 healthy controls. Decreased occipital cortex CMRO2 responses were observed in premanifest and early manifest HD patients compared to controls ( P < 0.001), correlating with the CAG-Age Product scores in these patients ( R2 = 0.4, P = 0.001). The results suggest the potential value of this reduced CMRO2 response during visual stimulation as a biomarker for HD and may illuminate the role of metabolic alterations in the pathophysiology of HD.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine,Neurology (clinical),Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1177/0271678X20949286

Reference82 articles.

1. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

2. CAG-repeat length and the age of onset in Huntington disease (HD): A review and validation study of statistical approaches

3. Huntington disease: natural history, biomarkers and prospects for therapeutics

4. Longitudinal change in regional brain volumes in prodromal Huntington disease

5. Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Towards high-resolution quantitative assessment of vascular dysfunction;Frontiers in Physics;2023-09-27

2. Functional and Physiological MRI Measures as Early Biomarkers for Huntington’s Disease;Contemporary Clinical Neuroscience;2023

3. Bilateral chorea due to hemodynamic ischemia associated with bilateral internal carotid artery stenosis: A case report;CNS Neuroscience & Therapeutics;2022-12-27

4. The brain vasculome;The Vasculome;2022

5. From Neurodevelopmental to Neurodegenerative Disorders: The Vascular Continuum;Frontiers in Aging Neuroscience;2021-10-20