Blood contamination of the pharmaceutical staff by irinotecan and its two major metabolites inside and outside a compounding unit

Author:

Béchet Victoire1,Benoist Hubert12ORCID,Beau Frédéric3,Divanon Fabienne3,Lagadu Stéphanie2,Sichel F2,Delépée Raphael2ORCID,Saint-Lorant Guillaume12ORCID

Affiliation:

1. Department of Pharmacy, CHU de Caen, Caen, France

2. UNICAEN, UNIROUEN, ABTE, Comprehensive Cancer Centre F. Baclesse, Normandie University, Caen, France

3. Departement of Pharmacy, Comprehensive Cancer Centre F. Baclesse, Caen, France

Abstract

Background Caregivers in healthcare settings are exposed to a risk of antineoplastic drug contamination which can lead to adverse health effects. Biological monitoring is necessary to estimate the actual level of exposure of these workers. This study was conducted with the aim of assessing blood contamination levels by irinotecan and its metabolites of pharmaceutical staff operating inside and outside a compounding unit. Methods The study took place within the pharmaceutical unit of a French comprehensive cancer centre. Blood samples were collected from the pharmacy workers operating inside and outside the compounding unit, and analysed by UHPLC-MS/MS. Plasma and red blood cell irinotecan and its metabolites (SN-38; APC) were determined with a validated analytical method detection test. Results A total of 17/78 (21.8%) plasma and red blood cell-based assays were found to be contaminated among staff. Overall, the total number of positive assays was significantly higher for staff members working outside the compounding unit than for workers working inside it ( P = 0.022), with respectively 5/42 (11.9%) and 12/36 (33.3%) positive assays. For plasma dosages, the “outside” group had a significantly higher number of positive assays ( P = 0.014). For red blood cell-based assays, no significant difference was found ( P = 0.309). Conclusions This study reveals that pharmaceutical staff serving in health care settings are exposed to a risk of antineoplastic drug contamination, not only inside the compounding room but also in adjacent rooms. The results would help to raise awareness and potentially establish protective measures for caregivers working in areas close to the compounding room as well.

Funder

Agence Régionale de Santé de Normandie

Publisher

SAGE Publications

Subject

Pharmacology (medical),Oncology

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