Affiliation:
1. Institute of Pharmaceutical Sciences of Western Switzerland (ISPSO), School of Pharmaceutical Sciences, University of Geneva, CMU, Geneva, Switzerland
2. Pharmacy, Geneva University Hospitals (HUG), Geneva, Switzerland
Abstract
Introduction Due to the high toxicity of antineoplastic drugs, handling their packaging could lead to the chemical contamination of hospital environments and exposure risks to healthcare professionals and patients. This study aimed to assess the contamination of two main surfaces: the outer primary packaging of oral antineoplastic drug formulations ( n = 36) available on the Swiss market and the surface of secondary packaging of injectable antineoplastic drug preparations ( n = 60) produced by the pharmacy of a Swiss hospital and carriers used for transport ( n = 5). Methods Samples were collected using a validated wipe sampling method. The simultaneous analysis of 24 antineoplastic drugs: 5-fluorouracil, busulfan, carboplatin, cyclophosphamide, cytarabine, dacarbazine, daunorubicin, docetaxel, doxorubicin, epirubicin, etoposide, gemcitabine, idarubicin, ifosfamide, irinotecan, methotrexate, oxaliplatin, paclitaxel, pemetrexed, raltitrexed, topotecan, treosulfan, vinblastine, vincristine) and 1 antiviral compound (ganciclovir) was performed by UHPLC–MS/MS. Results A total of 58% and 90% positive results were obtained for the primary packaging of oral chemotherapies and for the secondary packaging of injectable preparations, respectively. The highest quantities found on the primary packaging for oral chemotherapies and on the surface of closed leak-proof bags were 111 ng of methotrexate and 19 ng of gemcitabine, respectively. Gemcitabine (69%) and cyclophosphamide (38%) were the two most common contaminants found on the packaging of injectable preparations and carriers, regardless of the chemotherapy preparations. Conclusion Trace levels (ng) of antineoplastic drugs can be found on most surfaces of all evaluated pharmaceutical products. Thus, suitable personal protective equipment is mandatory for healthcare professional handling antineoplastic drugs.
Reference38 articles.
1. Survey of guidelines and current practices for safe handling of antineoplastic and other hazardous drugs used in 24 countries
2. CytoPrevent. CytoPrevent. 2021 [cité 23 mai 2023]. EU: Policy Recommendations—Preventing occupational exposure to cytotoxic and other hazardous drugs. Available on: https://cytoprevent.eu/2021/01/25/eu-policy-recommendations-preventing-occupational-exposure-to-cytotoxic-and-other-hazardous-drugs/
3. National Institute for Occupational Safety and Health (NIOSH). Preventing occupational exposures to antineoplastic and other hazardous drugs in health care settings. [Internet]. U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health; 2004 September [cité 22 mai 2023]. Available on: https://www.cdc.gov/niosh/docs/2004-165/
4. Studies on the decontamination of surfaces exposed to cytotoxic drugs in chemotherapy workstations