Affiliation:
1. Institute of Oncology, Istanbul University, Istanbul, Turkey
Abstract
Introduction Because classic Kaposi's sarcoma (CKS) is currently regarded as a low-grade vascular malignancy, it has been usually known as indolent clinical course. The slow-growing neoplasms are usually asymptomatic and rarely systematically progressive. Although CKS is a chronic disease which is rarely life-threatening, systemic therapy may be necessary in some patients with symptomatic skin or visceral involvement. Case report In this report, we presented a 92-year-old CKS man with widespread and symptomatic skin lesions. Management and outcome Patient was treated successfully with ultra-low dose oral etoposide; 50 mg/day for 7 days. Cycles were repeated in every 21 days. There was a dramatic regression in all lesions at the end of treatment; only skin colorations were persisted instead of palpable nodular lesions. Moreover, no serious hematological and non-hematological adverse events were observed. Discussion Fragile advanced CKS patients with advanced age and/or comorbitidies need to be considered to optimize outcomes. Treatment with single-agent oral chemotherapy, oral ultra-low dose etoposide, may be one of the effective treatment styles.
Subject
Pharmacology (medical),Oncology
Cited by
1 articles.
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1. Etoposide;Reactions Weekly;2022-10-08