Topical cidofovir–induced acute kidney injury in two severely immunocompromised patients with refractory multidrug-resistant herpes simplex virus infections-Reference-Cited by-同舟云学术

Topical cidofovir–induced acute kidney injury in two severely immunocompromised patients with refractory multidrug-resistant herpes simplex virus infections

Published:2014-12-07 Issue:2 Volume:22 Page:325-331
ISSN:1078-1552
Container-title:Journal of Oncology Pharmacy Practice
language:en
Short-container-title:J Oncol Pharm Pract

Author:

Saunders Ila M¹,Lahoti Amit²,Chemaly Roy F³,Trevino Cynthia⁴,Westmoreland Michael⁵,Hosing Chitra⁴

Affiliation:

1. UC San Diego Skaggs School of Pharmacy & Pharmaceutical Sciences, La Jolla, CA, USA (At the time of submission, Ila M Saunders was a Clinical Pharmacy Specialist in the Division of Pharmacy at The University of Texas MD Anderson Cancer Center, Houston, TX, USA)

2. Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

3. Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

4. Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

5. Division of Pharmacy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Abstract

Cidofovir, a nucleoside analog of deoxycytidine monophosphate, is a water-soluble polar molecule that exhibits antiviral activity against a broad range of DNA viruses. Cidofovir for injection is approved for the treatment of cytomegalovirus retinitis in patients with acquired immune deficiency syndrome. The safety and efficacy of topical cidofovir has been described in a limited number of patients. We present two cases of multidrug-resistant herpes simplex virus infections that responded to topical cidofovir therapy yet resulted in irreversible acute kidney injury.

Publisher

SAGE Publications

Subject

Pharmacology (medical),Oncology

Link

http://journals.sagepub.com/doi/pdf/10.1177/1078155214560921

Reference15 articles.

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