Off-label infusion of biosimilar bevacizumab: A provincial experience

Author:

Geirnaert Marc1ORCID,Howarth Jacy1,Kellett Curtis2,Martin Kristen1,Streilein Scott1,Ricard Chad2,Wasney Danica2,Niraula Saroj34

Affiliation:

1. Provincial Oncology Drug Program, CancerCare Manitoba, Winnipeg, Canada

2. Department of Pharmacy, CancerCare Manitoba, Winnipeg, Canada

3. Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada

4. Department of Medical Oncology and Hematology, CancerCare Manitoba, Winnipeg, Canada

Abstract

The product monograph for reference bevacizumab (Avastin) and biosimilar bevacizumab (Mvasi) recommend to infuse the first dose of bevacizumab over 90 min, second dose over 60 min and third and subsequent doses over 30 min. Despite the product monograph recommendations, many institutions adopted an accelerated bevacizumab (Avastin) 0.5 mg/kg/min infusion time. Our province adopted the accelerated infusion time at time of biosimilar bevacizumab (Mvasi) adoption. Our experience with the accelerated infusion time was well tolerated in the first five months of biosimilar bevacizumab adoption across different tumor types.

Publisher

SAGE Publications

Subject

Pharmacology (medical),Oncology

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