Bromocriptine for the treatment of postoperative cerebellar mutism syndrome in pediatric patients: Three case reports

Author:

Amor-García Miguel Á1ORCID,Fernández-Llamazares Cecilia M1ORCID,Manrique-Rodríguez Silvia1,Narrillos-Moraza Álvaro1,García-Morín Marina2,Huerta-Aragonés Jorge2ORCID,Sanjurjo-Sáez María1

Affiliation:

1. Pharmacy Service, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain

2. Section of Pediatric Hematology and Oncology, Department of Pediatrics, Hospital General Universitario Gregorio Marañón, Madrid, Spain

Abstract

Introduction Cerebellar mutism syndrome (CMS) is a common complication after posterior fossa tumor resection. It is characterized by a significant lack or loss of speech. Its biological origin remains unclear and there are no standardized treatments. However, bromocriptine seems to be a possible treatment for this condition. Case report In this paper, we present three cases of pediatric patients (4, 5, and 17-year old) who developed CMS after posterior fossa tumor surgery. They were treated with bromocriptine to improve neurological symptoms. Management and outcome: Bromocriptine was started at a low dose and was progressively increased to reach the minimum effective dose. After four months of treatment, a normal and fluid speech was observed in the three patients. No discontinuation due to adverse events were reported. Discussion Bromocriptine has shown to be an effective and safe treatment for CMS in pediatric patients after posterior fossa tumor resection.

Publisher

SAGE Publications

Subject

Pharmacology (medical),Oncology

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