The safety and pharmacokinetics of rapid iloprost aerosol delivery via the BREELIB nebulizer in pulmonary arterial hypertension

Author:

Gessler Tobias1,Ghofrani Hossein‐Ardeschir12,Held Matthias3,Klose Hans4,Leuchte Hanno5,Olschewski Horst6,Rosenkranz Stephan7,Fels Lueder8,Li Na9,Ren Dawn9,Kaiser Andreas8,Schultze‐Mosgau Marcus‐Hillert8,Müllinger Bernhard10,Rohde Beate8,Seeger Werner1

Affiliation:

1. Department of Internal Medicine IIUniversity of Giessen and Marburg Lung Center and Member of the German Center of Lung ResearchGiessenGermany

2. Department of MedicineImperial College LondonLondonUK

3. Respiratory Medicine and Cardiology SectionDepartment of Internal MedicineCenter for Pulmonary Hypertension and Pulmonary Vascular DiseaseMission Medical HospitalWürzburgGermany

4. Department of PneumologyUniversity Hospital Hamburg‐EppendorfHamburgGermany

5. Department of Internal Medicine IINeuwittelsbach Academic HospitalLudwig Maximilians UniversityMunichGermany

6. Division of PulmonologyMedical University of GrazGrazAustria

7. Department III of Internal Medicine and Cologne Cardiovascular Research CenterCologne University Heart CentreCologneGermany

8. Bayer AGBerlinGermany

9. Bayer HealthCare Company LtdBeijingChina

10. Vectura GmbHGautingGermany

Funder

Bayer

Publisher

Wiley

Subject

Pulmonary and Respiratory Medicine

Reference28 articles.

1. Bayer Pharma AG. Ventavis10 SmPC. Available at:http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_‐_Product_Information/human/000474/WC500048691.pdf(2016 accessed on 19 April 2016).

2. Actelion Pharma Ltd. Ventavis Prescribing information. Available at:http://www.accessdata.fda.gov/drugsatfda_docs/label/2008/021779s008lbl.pdf(2015 accessed on 13 July 2015).

3. Mechanisms of disease: pulmonary arterial hypertension;Schermuly RT;Nat Rev Cardiol,2011

4. Pulmonary arterial hypertension;Montani D;Orphanet J Rare Dis,2013

5. PATENT PLUS: a blinded, randomised and extension study of riociguat plus sildenafil in PAH;Galiè N;Eur Respir J,2015

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