Pembrolizumab and radiation therapy for multifocal myxofibrosarcoma of the scalp: a case report-Reference-Cited by-同舟云学术

Pembrolizumab and radiation therapy for multifocal myxofibrosarcoma of the scalp: a case report

Published:2024-01 Issue: Volume:16 Page:
ISSN:1758-8359
Container-title:Therapeutic Advances in Medical Oncology
language:en
Short-container-title:Ther Adv Med Oncol

Author:

Grant Christopher Ryan¹^ORCID,Arter Zhaohui²,Smith Janellen³,Seyedin Steven N.⁴,Nourbakhsh Mahra⁵,Lee Bonnie³⁵,Creadore Andrew³,Mar Nataliya²

Affiliation:

1. Department of Medicine, University of California Irvine Medical Center, 101 The City Drive South, Orange, CA 92868, USA

2. Division of Hematology/Oncology, University of California Irvine Medical Center, Orange, CA, USA

3. Department of Dermatology, University of California Irvine Medical Center, Orange, CA, USA

4. Department of Radiation Oncology, University of California Irvine Medical Center, Orange, CA, USA

5. Department of Pathology, University of California Irvine Medical Center, Orange, CA, USA

Abstract

Myxofibrosarcoma is one of the most common types of soft tissue sarcomas occurring in the lower limbs of male older adults. Mainstay treatment is surgical intervention with chemoradiotherapy with a combination of doxorubicin and ifosfamide with brachytherapy if advanced or metastatic. There are no guidelines on the combination of immunotherapy with radiation therapy for myxofibrosarcoma. We report the first documented case of unresectable multifocal myxofibrosarcoma that was treated with pembrolizumab and radiation therapy for first-line therapy with a significant response. We also highlight genomic markers and immune radiation priming therapy, forecasting favorable response in treatment with pembrolizumab.

Publisher

SAGE Publications

Link

https://journals.sagepub.com/doi/pdf/10.1177/17588359241259451

Reference42 articles.

1. Myxofibrosarcoma landscape: diagnostic pitfalls, clinical management and future perspectives

2. World Health Organization, Fletcher C, Bridge J, et al. WHO classification of tumours of soft tissue and bone: WHO classification of tumours, vol. 5. World Health Organization, https://portal.research.lu.se/en/publications/who-classification-of-tumours-of-soft-tissue-and-bone-who-classif (2013, accessed 28 February 2024).

3. Epidemiology and Etiology of Sarcomas

4. Soft-tissue sarcomas

5. Brennan MF, Antonescu CR, Alektiar KM, et al. Management of soft tissue sarcoma. Chap 8, 2016, pp, 143–152.