Metastatic Urothelial Cancer: a rapidly changing treatment landscape

Author:

Stecca Carlos1ORCID,Abdeljalil Osama1,Sridhar Srikala S.2

Affiliation:

1. Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, ON, Canada

2. Professor, University of Toronto, Medical Oncologist, Princess Margaret Cancer Center, Chair, GU Medical Oncologists of Canada, 7-625 -700 University Avenue, Toronto, ON M5G 2M9, Canada

Abstract

Despite significant progress, metastatic urothelial cancer remains an incurable condition with a limited life expectancy. Platinum-based chemotherapy is still the mainstay of treatment for metastatic disease, but immunotherapy, antibody drug conjugates, and targeted agents have shown encouraging results in several recent practice changing trials. In this review, we discuss the standard of care, recent therapeutic advances, ongoing clinical trials, and future perspectives in metastatic urothelial carcinoma.

Publisher

SAGE Publications

Subject

Oncology

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