Unraveling the tumor immune microenvironment of lung adenocarcinoma using single-cell RNA sequencing

Author:

Song Lele1ORCID,Gong Yuan2,Wang Erpeng3ORCID,Huang Jianchun4,Li Yuemin5

Affiliation:

1. Department of Oncology, Chinese PLA General Hospital, Beijing, P.R. China

2. Department of Gastroenterology, The Second Medical Center of the Chinese PLA General Hospital, Beijing, P.R. China

3. The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong province, P.R. China

4. Department of Thoracic Surgery, The First Affiliated Hospital of Kunming Medical University. No. 295, Xichang Road, Wuhua District, Kunming, Yunnan Province 650032, P.R. China

5. Department of Oncology, Chinese PLA General Hospital. No.8, Dongdajie, Fengtai District, Beijing 100071, P.R. China

Abstract

Tumor immune microenvironment (TIME) and its indications for lung cancer patient prognosis and therapeutic response have become new hotspots in cancer research in recent years. Tumor cells, immune cells, various regulatory factors, and their interactions in the TIME have been suggested to commonly influence lung cancer development and therapeutic outcome. The heterogeneity of TIME is composed of dynamic immune-related components, including various cancer cells, immune cells, cytokine/chemokine environments, cytotoxic activity, or immunosuppressive factors. The specific composition of cell subtypes may facilitate or hamper the response to immunotherapy and influence patient prognosis. Various markers have been found to stratify the patient prognosis or predict the therapeutic outcome. In this article, we systematically reviewed the recent advancement of TIME studies in lung adenocarcinoma (LUAD) using single-cell RNA sequencing (scRNA-seq) techniques, with specific focuses on the roles of TIME in LUAD development, TIME heterogeneity, indications of TIME in patient prognosis and therapeutic response during immunotherapy and drug resistance. The main findings in TIME heterogeneity and relevant markers or models for prognosis stratification and response prediction have been summarized. We hope that this review provides an overview of TIME status in LUAD and an inspiration for future development of strategies and biomarkers in LUAD treatment.

Funder

national key research and development program of china

Publisher

SAGE Publications

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