Air Pollution and Human Sperm Sex Ratio

Author:

Radwan Michał12,Dziewirska Emila3,Radwan Paweł2,Jakubowski Lucjusz4,Hanke Wojciech3,Jurewicz Joanna3

Affiliation:

1. Department of Public Health Sciences, The State University of Applied Sciences in Plock, Plock, Poland

2. Department of Gynecology and Reproduction, “Gameta” Hospital, Rzgów, Poland

3. Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland

4. Department of Medical Genetics, Polish Mother’s Memorial Hospital—Research Institute, Lodz, Poland

Abstract

The present study was designed to address the hypothesis that exposure to specific air pollutants may impact human sperm Y:X chromosome ratio. The study population consisted of 195 men who were attending an infertility clinic for diagnostic purposes and who had normal semen concentration of 15–300 mln/ml (WHO, 2010). Participants represented a subset of men in a multicenter parent study conducted in Poland to evaluate environmental factors and male fertility. Participants were interviewed and provided a semen sample. The Y:X ratio was assessed by fluorescent in situ hybridization (FISH). Air quality data were obtained from the AirBase database. In multivariate analysis the significant reduction was observed in the proportion of Y/X chromosome bearing sperm and exposure to particulate matter >10 μm in aerodynamic diameter PM10 ( p = .009) and particulate matter <10 μm in aerodynamic diameter PM2.5 ( p = .023). The observed effects of a lower Y:X sperm chromosome ratio among men exposed to air pollution support the evidence that the trend of declining sex ratio in several societies over past decades has been due to exposure to air pollution; however due to limited data on this issue, the obtained results should be confirmed in longitudinal studies.

Publisher

SAGE Publications

Subject

Public Health, Environmental and Occupational Health,Health(social science)

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