Growth Hormone Secretagogue Treatment in Hypogonadal Men Raises Serum Insulin-Like Growth Factor-1 Levels

Author:

Sigalos John T.1,Pastuszak Alexander W.23,Allison Andrew23,Ohlander Samuel J.4,Herati Amin5,Lindgren Mark C.6,Lipshultz Larry I.23

Affiliation:

1. Baylor College of Medicine, Houston, TX, USA

2. Center for Reproductive Medicine, Baylor College of Medicine, Houston, TX, USA

3. Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA

4. University of Illinois at Chicago College of Medicine, Chicago, IL, USA

5. The Brady Urological Institut, John’s Hopkins Bayview Medical Center Baltimore, MD, USA

6. University of Oklahoma College of Medicine, Department of Urology, Oklahoma City, OK, USA

Abstract

Realizing the reported misuse of human growth hormone (GH), investigation of a safe alternative mechanism for increasing endogenous GH is needed. Several GH secretagogues are available, including GH-releasing peptides (GHRPs) GHRP-2 and GHRP-6, and the GH-releasing hormone analog, sermorelin (SERM). Insulin-like growth factor 1 (IGF-1) serves as a surrogate marker for GH. Here, the effect of GHRP/SERM therapy on IGF-1 levels is evaluated. A retrospective review of medical records was performed for 105 men on testosterone (T) therapy seeking increases in lean body mass and fat loss who were prescribed 100 mcg of GHRP-6, GHRP-2, and SERM three times daily. Compliance with therapy was assessed, and 14 men met strict inclusion criteria. Serum hormone levels of IGF-1, T, free T (FT), estradiol (E), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) were evaluated. Mean (SD) age of the cohort was 33.2 (2.9) years, and baseline IGF-1 level was 159.5 (26.7) ng/mL. Mean (SD) duration of continuous GHRP/SERM treatment was 134 (88) days. Mean posttreatment IGF-1 level was 239.0 (54.6) ng/mL ( p < .0001). Three of the 14 men were on an aromatase inhibitor and/or tamoxifen prior to treatment and another 4 men were coadministered an aromatase inhibitor and/or tamoxifen during treatment. Inhibition of E production or estrogen receptor blockade resulted in smaller increases in IGF-1 levels. GHRP/SERM therapy increases serum IGF-1 levels with strict compliance to thrice-daily dosing. The results suggest that combination therapy may be beneficial in men with wasting conditions that can improve with increased GH secretion.

Publisher

SAGE Publications

Subject

Public Health, Environmental and Occupational Health,Health (social science)

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