An Alternative to Laboratory Animal Experimentation for Human Health Risk Assessment: Epidemiological Studies of Pet Animals

Author:

Glickman Lawrence T.1,Domanski Linda M.1

Affiliation:

1. Section of Epidemiology, Department of Clinical Studies, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, PA 19104–6010, USA

Abstract

Alternative approaches to the use of laboratory animals for human health risk assessment have traditionally utilised in vitro techniques. We propose an expanded concept of an alternative to include epidemiological studies of pet animals with spontaneously occurring disease. Compared with humans, the use of pet animals has the advantage of a shorter latent period for development of most diseases and is less confounded by occupational exposures or self-selected personal exposures such as alcohol and tobacco consumption. In contrast to laboratory animal experiments, spontaneous tumours in pets reflect natural exposures to a wide variety of environmental carcinogens, which may be more sensitive for the evaluation of the effects of complex low level ambient exposures, such as air pollutants. Sources of data on pet populations and their diseases are described and examples of epidemiological studies in pet animals are presented. Unlike laboratory animal experiments which primarily benefit humans, research into the cause, prevention, and treatment of spontaneously occurring diseases in pet animals may benefit the individual animal and the species.

Publisher

SAGE Publications

Subject

Medical Laboratory Technology,Toxicology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference48 articles.

1. AN EPIDEMIOLOGIC PERSPECTIVE OF ENVIRONMENTAL CARCINOGENESIS

2. DollR., and PetoR. (1981). The Causes of Cancer, 117 pp. New York: Oxford University Press.

3. Carcinogenic effects of chronic exposure to very low levels of toxic substances.

Cited by 9 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3