Improving Design and Analysis of Research: Lessons from Clinical Research-Reference-Cited by-同舟云学术

Improving Design and Analysis of Research: Lessons from Clinical Research

Published:2004-09 Issue:2_suppl Volume:32 Page:31-39
ISSN:0261-1929
Container-title:Alternatives to Laboratory Animals
language:en
Short-container-title:Altern Lab Anim

Author:

Altman Douglas G.¹

Affiliation:

1. Cancer Research UK/NHS Centre for Statistics in Medicine, Institute of Health Sciences, Headington, Oxford OX3 7LF, UK

Abstract

There is a clear need to optimise the use of animals in research and to ensure that the studies that are done make a worthwhile contribution to scientific knowledge. Research that has an inappropriate study design, or is improperly analysed or interpreted, may mislead and is not defensible. Published reviews of the quality of design and analysis in clinical studies are used to see what lessons can be drawn in respect of animal research. The need for clear and full reporting of research is discussed.

Publisher

SAGE Publications

Subject

Medical Laboratory Technology,Toxicology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/026119290403202s08

Reference47 articles.

1. APPLICATION OF STATISTICAL METHODS IN PHYSIOLOGY

2. WHAT IS WRONG WITH THE MEDICAL CURRICULUM ?

3. Statistics and ethics in medical research. Misuse of statistics is unethical.

4. The scandal of poor medical research

5. The Prevalence of Negative Studies with Inadequate Statistical Power

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