Lack of Predictivity of the Rat Lethality (LD50) Test for Ecological and Human Health Effects-Reference-Cited by-同舟云学术

Lack of Predictivity of the Rat Lethality (LD50) Test for Ecological and Human Health Effects

Published:2005-02 Issue:1 Volume:33 Page:9-19
ISSN:0261-1929
Container-title:Alternatives to Laboratory Animals
language:en
Short-container-title:Altern Lab Anim

Author:

Rosenkranz Herbert S.¹,Cunningham Albert R.²

Affiliation:

1. Department of Biomedical Sciences, Florida Atlantic University, Boca Raton, FL, USA;

2. Department of Environmental Studies, Louisiana State University, Baton Rouge, LA, USA

Abstract

The relationship between acute toxicity in rats (LD50 values) and indicators of potential health hazards in humans was investigated, based on a chemical population-based paradigm (i.e. the “chemical diversity approach”). These structure–activity relationship-based analyses indicate that high toxicity in rats (i.e. a low LD50 value) is not a good predictor of health effects in humans. In fact, it was found that high acute toxicity to minnows, as well as toxicity to cultured cells, showed significantly greater associations with the potential for health effects than rat LD50 values.

Publisher

SAGE Publications

Subject

Medical Laboratory Technology,Toxicology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/026119290503300104

Reference79 articles.

1. OECD (2001). Harmonised Integrated Classification System for Human Health and Environmental Hazards of Chemical Substances and Mixtures. ENV/JM/MONO(2001)6, 247 pp. Paris, France: Organisation for Economic Co-operation and Development.

2. REACHing for chemical safety.

3. The Practice of Structure Activity Relationships (SAR) in Toxicology

4. (Q)SARS: gatekeepers against risk on chemicals?

5. Use of QSARs in international decision-making frameworks to predict ecologic effects and environmental fate of chemical substances.

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Quantitative Measurements of Pharmacological and Toxicological Activity of Molecules;Chemistry;2022-11-08

2. Non-animal Replacements for Acute Toxicity Testing;Alternatives to Laboratory Animals;2015-07

3. Acute toxicology testing;Principles of Toxicology Testing, Second Edition;2013-04-02

4. Acute Toxicology Testing;Principles of Toxicology Testing;2007-07-23

5. Comparative Quantitative Structure–Activity–Activity Relationships for Toxicity to Tetrahymena pyriformis and Pimephales promelas;Alternatives to Laboratory Animals;2007-03