Strategies to Replace in Vivo Acute Systemic Toxicity Testing: The Report and Recommendations of ECVAM Workshop 50,

Author:

Gennari Alessandra1,van den Berghe Christine2,Casati Silvia1,Castell José3,Clemedson Cecilia4,Coecke Sandra1,Colombo Alessandra5,Curren Rodger6,Negro Gianni Dal7,Goldberg Alan8,Gosmore Catherine9,Hartung Thomas1,Langezaal Ingrid10,Lessigiarska Iglika10,Maas Wilfred11,Mangelsdorf Inge12,Parchment Ralph13,Prieto Pilar1,Sintes Juan Riego10,Ryan Michael14,Schmuck Gabriele15,Stitzel Katherine16,Stokes William17,Vericat Joan-Albert,Gribaldo Laura1

Affiliation:

1. ECVAM, Institute for Health & Consumer Protection, European Commission Joint Research Centre, Ispra, Italy;

2. L'Oréal Research, Aulnay sous Bois, France;

3. Departamento de Bioquímica Facultad Medicina/Centro de Investigación Hospital Universitario La Fe, Valencia, Spain;

4. Expertrådet AB, Sundbyberg, Sweden;

5. Direzione Salute, Sicurezza e Ambiente — Sicurezza Prodotti Polimeri Europa, San Donato Milanese, Italy;

6. Institute for In Vitro Sciences, Gaithersburg, MD, USA;

7. DVM-Medicines Safety Evaluation, GlaxoSmithKline Medicines Research Centre, Safety, Verona, Italy;

8. Center for Alternatives to Animal Testing, Johns Hopkins University, Baltimore, MD, USA;

9. Health and Safety Executive, Bootle, Merseyside, UK;

10. European Chemicals Bureau, Institute for Health & Consumer Protection, European Commission Joint Research Centre, Ispra, Italy;

11. Physiological Sciences Department, TNO Chemistry, Zeist, The Netherlands;

12. Fraunhofer, Department of Chemical Risk Assessment, Institute of Toxicology and Experimental Medicine, Hannover, Germany;

13. SciTech Development, Grosse Pointe, MI, USA;

14. Department of Pharmacology, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland;

15. Bayer, Project Managment AH PH-PD Toxicology, Germany;

16. West Chester, OH, USA;

17. National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA; NeuroPharma, Madrid, Spain

Publisher

SAGE Publications

Subject

Medical Laboratory Technology,Toxicology,General Biochemistry, Genetics and Molecular Biology,General Medicine

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