Comparing In Vivo, In Vitro and In Silico Methods and Integrated Strategies for Chemical Assessment: Problems and Prospects

Author:

Benfenati Emilio1,Gini Giuseppina2,Hoffmann Sebastian3,Luttik Robert4

Affiliation:

1. Istituto di Ricerche Farmacologiche ‘Mario Negri’, Milano, Italy

2. Dipartimento di Elettronica e Informazione, Politecnico di Milano, Milano, Italy

3. TÜV Rheinland, BioTech GmbH, Köln, Germany

4. National Institute for Public Health and the Environment, Bilthoven, The Netherlands

Abstract

The RAINBOW workshop addressed the background for the integration of in vivo, in vitro and computer-based ( in silico) methods, to facilitate the study of the toxic properties of chemicals. On the basis of these discussions, we prepared the present paper, outlining the strengths, weaknesses, opportunities and threats of each approach, both alone and integrated into a single testing strategy. The current scheme for evaluation of chemicals needs to be reshaped, in the face of the much larger numbers of chemicals which need to be examined and the availability of a diversified set of tools.

Publisher

SAGE Publications

Subject

Medical Laboratory Technology,Toxicology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference25 articles.

1. Predicting Chemical Toxicity and Fate

2. OECD (2005). Guidance Document on the Validation and International Acceptance of New or Updated Test Methods for Hazard Identification. Environmental Health and Safety Monograph Series on Testing and Assessment, No. 34, 96pp. Paris, France: Organisation for Economic Co-operation and Development.

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