Toxicity Assessment of Tobacco Products in Vitro-Reference-Cited by-同舟云学术

Toxicity Assessment of Tobacco Products in Vitro

Published:2015-03 Issue:1 Volume:43 Page:39-67
ISSN:0261-1929
Container-title:Alternatives to Laboratory Animals
language:en
Short-container-title:Altern Lab Anim

Author:

Manuppello Joseph R.¹,Sullivan Kristie M.²

Affiliation:

1. People for the Ethical Treatment of Animals, Norfolk, VA, USA

2. Physicians Committee for Responsible Medicine, Washington, DC, USA

Abstract

Driven by new regulatory demands to demonstrate risk reduction, the toxicity assessment of tobacco products increasingly employs innovative in vitro methods, including biphasic cell and tissue cultures exposed to whole cigarette smoke at the air–liquid interface, cell transformation assays, and genomic analyses. At the same time, novel tobacco products are increasingly compared to traditional cigarettes. This overview of in vitro toxicology studies of tobacco products reported in the last five years provides evidence to support the prioritisation of in vitro over in vivo methods by industry and their recommendation by regulatory authorities.

Publisher

SAGE Publications

Subject

Medical Laboratory Technology,Toxicology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/026119291504300108

Reference68 articles.

1. IOM (2012). Scientific Standards for Studies on Modified Risk Tobacco Products, 370pp. Washington, DC, USA: The National Academies Press.

2. Evaluation of In vitro Assays for Assessing the Toxicity of Cigarette Smoke and Smokeless Tobacco

3. A review of in vitro cigarette smoke exposure systems

4. An inter-machine comparison of tobacco smoke particle deposition in vitro from six independent smoke exposure systems

5. Quantification of Cigarette Smoke Particle DepositionIn VitroUsing a Triplicate Quartz Crystal Microbalance Exposure Chamber

Cited by 16 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Evaluation of Cytotoxicity and Oxidative Stress of Whole Aerosol from Vuse Alto ENDS Products;Toxics;2024-02-04

2. Population-based birth cohort study on diabetes in pregnancy and infant hospitalisations in Cree, other First Nations and non-Indigenous communities in Quebec;BMJ Open;2023-12

3. Effects of smokeless tobacco on cell viability, reactive oxygen species, apoptosis, and inflammatory cytokines in human umbilical vein endothelial cells;Toxicology Mechanisms and Methods;2021-02-09

4. Nonanimal toxicology testing approaches for traditional and deemed tobacco products in a complex regulatory environment: Limitations, possibilities, and future directions;Toxicology in Vitro;2020-02

5. A Replacement Perspective on Inhalation Toxicology;The History of Alternative Test Methods in Toxicology;2019