Spindle-Inhibiting Effects of Organotin Compounds: Effects of Trimethyltin on Chromosome Length-Reference-Cited by-同舟云学术

Spindle-Inhibiting Effects of Organotin Compounds: Effects of Trimethyltin on Chromosome Length

Published:1990-03 Issue:3 Volume:17 Page:195-198
ISSN:0261-1929
Container-title:Alternatives to Laboratory Animals
language:en
Short-container-title:Altern Lab Anim

Author:

Jensen Klaus Gjervig¹,Andersen Ole¹,Rønne Mogens²

Affiliation:

1. Department of Environmental Medicine, Odense University, Campusvej 55, 5230 Odense M., Denmark

2. Winslow Institute of Human Anatomy, Odense University, Campusvej 55, 5230 Odense M., Denmark

Abstract

Organotin compounds have a number of industrial applications, and human exposures occur in various industrial settings. The present study reports effects of trimethyltin chloride (TMT) on chromosome length in asynchronous human peripheral lymphocyte cultures. The results demonstrate dose-related and exposure time-related reductions in average chromosome length. Induction of supercontraction indicates that TMT is a powerful inhibitor of spindle function. TMT would thus be expected to be able to induce aneuploidy due to non-disjunction. This study indicates the need for more-direct investigations on the spindle-inhibiting effects of TMT and other organotin compounds.

Publisher

SAGE Publications

Subject

Medical Laboratory Technology,Toxicology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/026119299001700312

Reference17 articles.

1. Perspectives in mutation epidemiology: 3. Contribution of chromosome abnormalities to human morbidity and mortality and some comments upon surveillance of chromosome mutation rates

2. Polyploidy and aneuploidy by colcemid in Drosophila melanogaster