The Use of Biokinetics and in Vitro Methods in Toxicological Risk Evaluation

Author:

Blaauboer Bas J.1,Bayliss Martin K.2,Castell Jose V.3,Evelo Chris T.A.4,Frazier John M.5,Groen Kees6,Gülden Michael7,Guillouzo André8,Hissink Arendina M.9,Houston J. Brian10,Johanson Gunnar11,de Jongh Joost1,Kedderis Gregory L.12,Reinhardt Christoph A.13,van de Sandt Johannes J.M.9,Semino Giovanna14

Affiliation:

1. RITOX, Utrecht University, 3508 TD Utrecht, The Netherlands

2. Department of Bioanalysis and Drug Metabolism, Glaxo Wellcome, Park Road, Ware, Herts. SG12 ODP, UK

3. Unidad de Hepatologia Experimental, Hospital Universitario La Fe, Avda de Campanar 21, 46009 Valencia, Spain

4. Department of Pharmacology, Section of Toxicology, University of Limburg, 6200 MD Maastricht, The Netherlands

5. US Air Force, Armstrong Laboratory, Wright Patterson Air Force Base, OH 45433, USA

6. Department of Clinical Pharmacokinetics, Janssen Research Foundation, Turnhoutseweg 30, 2340 Beerse, Belgium

7. Cell Toxicology Section, Institute of Toxicology, University of Kiel, Weimarer Strasse 8, 24106 Kiel, Germany

8. INSERM U49, Unité de Recherches Hépatologiques, Hôpital de Pontchaillou, 35033 Rennes Cedex, France

9. Toxicology Division, TNO Nutrition and Food Research Institute, 3700 AJ Zeist, The Netherlands

10. Department of Pharmacy, The University of Manchester, Oxford Road, Manchester M13 9PL, UK

11. Department of Toxicology and Chemistry, National Institute for Working Life, 171 84 Solna, Sweden

12. Chemical Industry Institute of Toxicology CIIT, Research Triangle Park, NC 27709, USA

13. Swiss Alternatives to Animal Testing (SAAT), P.O. Box 14, 8614 Bertschikon-Zurich, Switzerland

14. Laboratory of Toxicology, Institute of Pharmacological Sciences, Via Balzaretti 9, 20133 Milan, Italy.

Publisher

SAGE Publications

Subject

Medical Laboratory Technology,Toxicology,General Biochemistry, Genetics and Molecular Biology,General Medicine

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