Proto-Oncogene Raf-1 as an Autoantigen in Meniere's Disease

Author:

Cheng Kuang-Chuan1,Matsuoka Hiroshi2,Lee Kyung Mi3,Kwon Soon Seog3,Kim Nacksung4,Mora Massimilliano5,Krug Marc S.6,Yoo T. J.7

Affiliation:

1. Raritan, New Jersey

2. Kyoto, Japan

3. Seoul, Korea

4. New York, New York

5. Genoa, Italy

6. Glen Mills, Pennsylvania

7. Memphis, Tennessee

Abstract

The 28 kd protein extracted from the guinea pig inner ear membranous fraction, which reacted with sera from patients with Meniere's disease, has been subjected to microsequencing. Nineteen amino acids were obtained (IVQQFGFQRRASDDGKLTQ). A protein data bank search showed that this sequence corresponded to residues 41 to 60 of human Raf-1 protein. Sera from 16 of 27 patients with Meniere's disease showed reactivity to the recombinant purified glutathione-S-transferase–Raf-1 protein. These results support the hypothesis that a subgroup of patients who suffer from Meniere's disease, as well as some other kinds of autoimmune inner ear diseases, have an autoantibody against Raf-1 protein.

Publisher

SAGE Publications

Subject

General Medicine,Otorhinolaryngology

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