Treatment of Papillomatosis of the Larynx with Transfer Factor

Abstract

Transfer factor was used in two patients with laryngeal papillomatosis in an attempt to influence the thymus dependent small lymphocytes to become immunologically effective in their attempt to control the lesions. Following transfer factor, therapy laboratory tests showed altered reactivity of the lymphocyte stimulation tests for delayed hypersensitivity, and the results of the in vitro lymphocyte cytotoxic assay suggested that transfer factor improved the ability of lymphocytes to kill the tumor cells. Clinically, a change in the skin responses to the tests of delayed hypersensitivity was observed, and a change in the endoscopic appearance of the lesions occurred. Histologically, the specimens showed a marked influx of immune cells when transfer factor was being administered. Finally there was a significant clinical improvement in the disease state.