Auditory Nerve and Brain Stem Evoked Response Thresholds in Infants Treated with Gentamicin as Neonates

Author:

Adelman Cahtia1,Linder Nejama1,Levi Haya1

Affiliation:

1. Jerusalem, Israel

Abstract

Thirty-two infants (18 full-term and 14 premature) who had been treated with gentamicin as neonates were examined to ascertain whether this drug induced hearing loss, even of low severity. Objective thresholds to clicks were obtained using auditory nerve and brain stem evoked responses. In addition, behavioral audiometry was performed. Serum concentrations before and after gentamicin treatment were at therapeutic levels. All infants were examined at least 1 1/4 months after cessation of therapy. Normal thresholds were obtained in all ears, with the exception of two with demonstrable middle ear effusion. It appears that gentamicin in therapeutic doses and serum concentrations, in the absence of renal insufficiency, does not cause hearing loss in neonates.

Publisher

SAGE Publications

Subject

General Medicine,Otorhinolaryngology

Cited by 14 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. NEONATAL SENSORINEURAL HEARING LOSS ASSOCIATED WITH FUROSEMIDE: A CASE-CONTROL STUDY;Developmental Medicine & Child Neurology;2008-11-12

2. Safety of Gentamicin Administered by Intravenous Bolus in the Nursery;Clinical Pediatrics;1999-07

3. Once-daily Gentamicin Dosing in Newborn Infants;Pediatrics;1999-06-01

4. Tobramycin population pharmacokinetics in neonates*;Clinical Pharmacology & Therapeutics;1997-10

5. Delayed post-neonatal intensive care unit hearing disturbance;International Journal of Pediatric Otorhinolaryngology;1996-01

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