Posttransplant Lymphoproliferative Disease Presenting as Sudden Respiratory Arrest in a Three-Year-Old Child

Author:

Hague Karin1,Catalano Peter1,Strauchen James1,Rothschild Michael1,Fyfe Billie2

Affiliation:

1. New York, New York

2. Philadelphia, Pennsylvania

Abstract

Posttransplant lymphoproliferative disease (PTLD) is an occasional complication of pediatric organ transplantation that, heretofore, has not been associated with airway obstruction. We report the first documented case of PTLD associated with complete airway obstruction resulting in sudden respiratory arrest and death in a 3-year-old child. This is contrasted to a subsequent case of PTLD wherein heightened clinical suspicion and prompt tonsillectomy resulted in a definitive diagnosis and improved outcome. The early clinical hallmarks of PTLD are a mononucleosis-like syndrome, tonsillar enlargement, and positive Epstein-Barr virus seroconversion. The potential for a fatal outcome of PTLD involving Waldeyer's ring components warrants early recognition and aggressive treatment.

Publisher

SAGE Publications

Subject

General Medicine,Otorhinolaryngology

Cited by 17 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Airway Obstruction due to Post-transplant Lymphoproliferative Disorder in a Pediatric Patient;Ear, Nose & Throat Journal;2019-11-24

2. Posttransplant Lymphoproliferative Disorder: Otolaryngological Manifestations and Management;Otolaryngology–Head and Neck Surgery;2017-05-23

3. Post-transplant lymphoproliferative disorder of the pediatric airway: Presentation and management;International Journal of Pediatric Otorhinolaryngology;2016-07

4. Posttransplant Lymphoproliferative Disorder involving the Larynx;International Journal of Head and Neck Surgery;2016

5. Pediatric Otolaryngology;Anesthesiology and Otolaryngology;2012-12-11

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